In plants and microorganisms, aspartate is the precursor to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. 1976 Jan 20;420(1):165-76. doi: 10.1016/0005-2795(76)90355-x. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases. Chemical and physical properties of Aspartic acid. The biological roles of its counterpart, "D-aspartic acid" are more limited. Molecular structure. Srpskohrvatski / српскохрватски, Programme International sur la Sécurité des Substances Chimiques, The Institute for Environmental Modeling (TIEM), Datation par racémisation des acides aminés, http://www.chemie.fu-berlin.de/chemistry/bio/aminoacid/asp_en.html, Acides aminés non protéinogènes présents dans des protéines, Autres acides aminées non protéinogènes, Portail de la biologie cellulaire et moléculaire, https://fr.wikipedia.org/w/index.php?title=Acide_aspartique&oldid=178957223, Portail:Biologie cellulaire et moléculaire/Articles liés, Portail:Sciences humaines et sociales/Articles liés, licence Creative Commons attribution, partage dans les mêmes conditions, comment citer les auteurs et mentionner la licence, Se décompose au-dessous du point d'ébullition Ã. Il est caractérisé par la présence d'un groupe carboxyle –COOH à l'extrémité de sa chaîne latérale, lui conférant un point isoélectrique de 2,77, ce qui en fait le résidu le plus acide dans les protéines. Il s'agit d'un acide dicarboxylique, et donc d'une molécule polaire. L'acide aspartique représente 40 % des produits de dégradation de l’aspartame[12]. In addition, aspartic acid acts as a hydrogen acceptor in a chain of ATP synthase. The conversion of aspartate to these other amino acids begins with reduction of aspartate to its "semialdehyde", O2CCH(NH2)CH2CHO. Include hydrogen atoms. Un article de Wikipédia, l'encyclopédie libre. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Aspartic acid, like glutamic acid, is classified as an acidic amino acid, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment, and could be as high as 14. Aspartic acid and glutamic acid are amino acids that have an additional carboxyl group that can release a proton and acquire a negative charge at the pH of body fluids. Structure, properties, spectra, suppliers and links for: DL-Aspartic acid, 617-45-8, Aspartic acid. It is a metabolite in the urea cycle and participates in gluconeogenesis. La dernière modification de cette page a été faite le 18 janvier 2021 à 22:28. It carries reducing equivalents in the malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartic acid is one of two acidic amino acids. [citation needed], Aspartate has many other biochemical roles. Aspartic acid (symbol Asp or D; the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins. γ = 90,00 Â° Structure, properties, spectra, suppliers and links for: L-(+)-Aspartic acid, 56-84-8, Aspartic acid, L-Aspartic acid. The 20 most common amino acids found in proteins are: Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glutamine, Glycine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine and Valine. Amphiphilic Optimization Enables Polyaspartamides with Effective Kinetic Inhibition of Tetrahydrofuran Hydrate Formation: Structure–Property Relationships. Aspartic Acid Chemical structure of Aspartic acid. L'acide aspartique participe à la gluconéogenèse et il joue un rôle de substrat de la voie de biosynthèse des pyrimidines. < 1%) of the total SAP market. [improper synthesis?] Current applications include biodegradable polymers (polyaspartic acid), low calorie sweeteners (aspartame), scale and corrosion inhibitors, and resins. Aspartic Acid Structure And Types Of Aspartic Acid Aspartic acid is a dicarboxylic amino acid that means it is an acidic polar α-amino acid with two carboxylic groups and one of the carboxyl groups is attached with one additional methylene group. If generated, an InChI string will also be generated and made available for searching. C'est un neurotransmetteur[8],[9] excitant du cerveau sous sa forme méthylée (N-méthyl-D-aspartate), activant les récepteurs NMDA, qui sont des récepteurs au glutamate. *Please select more than one item to compare In contrast, the repeating unit of synthetic polyaspartic acid may exist in four isomeric forms, depending on the stereochemistry of starting material (D - and L - aspartic acid) and synthetic procedure leading to α and β links. Because aspartate can be synthesized by the body it is classified as a non-essential amino acid. Superabsorbent polymers market - global industry analysis, size, share, growth, trends and forecase, 2014-2020. Here we present crystal structures of the Erwinia chrysanthemi l-asparaginase in complex with l-aspartic acid and with l-glutamic acid. Search results for aspartic acid at Sigma-Aldrich. Aspartic acid is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans. Aspartic acid and oxaloacetate, a compound that is known to boost brain health, are interconvertible and can transfer from one amino group to another. Symbol: Three-letter code - Asp. Include hydrogen atoms. [citation needed], In the human body, aspartate is most frequently synthesized through the transamination of oxaloacetate. Functions of L-Aspartic acid in the body. Aspartic acid has the isoelectric point of 2.77, because of these two carboxylic groups. α = 90,00 Â° 2021-2024 Aspartic Acid Market Forecast with Cost, Profit, Market Shares, Supply, Demands, Aspartic Acid market trend, Import and Export. Comparison with the structure of the wild-type enzyme reveals that, as originally intended, replacement of the catalytic base Glu-165 with the shorter side chain of aspartic acid has increased the distance between the base and the intermediate analog by 1 A. In proteins aspartate sidechains are often hydrogen bonded to form asx turns or asx motifs, which frequently occur at the N-termini of alpha helices. Ce produit n'est pas contrôlé selon les critères de classification du SIMDUT.

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